Saccharide-assisted resolution of bioactive chiral carboxylic acids via NHC-catalyzed regioselective transesterification

• Main Authors: Dai, Shuolu, Zou, Juan, Wang, Haiqi, Xu, Min, Xu, Erjuan, Song, Jia, Hong, Yu, Li, Shaojun, Lv, Wen-Xin, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Chiral auxiliary; Dynamic kinetic resolution
• Online Access: https://hdl.handle.net/10356/180831
• Institution: Nanyang Technological University

The utility of unprotected saccharides as chiral auxiliaries in asymmetric synthesis remains largely undeveloped despite their ready availability, configurational diversity, and chiral purity. Here, we disclose an efficient achiral NHC catalytic strategy to regioselectively install racemic α,α-disub...