Saccharide-assisted resolution of bioactive chiral carboxylic acids via NHC-catalyzed regioselective transesterification

• المؤلفون الرئيسيون: Dai, Shuolu, Zou, Juan, Wang, Haiqi, Xu, Min, Xu, Erjuan, Song, Jia, Hong, Yu, Li, Shaojun, Lv, Wen-Xin, Chi, Robin Yonggui
• مؤلفون آخرون: School of Chemistry, Chemical Engineering and Biotechnology
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Chemistry; Chiral auxiliary; Dynamic kinetic resolution
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/180831
• المؤسسة: Nanyang Technological University

The utility of unprotected saccharides as chiral auxiliaries in asymmetric synthesis remains largely undeveloped despite their ready availability, configurational diversity, and chiral purity. Here, we disclose an efficient achiral NHC catalytic strategy to regioselectively install racemic α,α-disub...