Total synthesis of (-)-deglycocadambine

• Main Authors: Wang, Fang-Xin, Chen, Ying-Tao, Liu, Hui, Wang, Heng-Shan, Liang, Hong, Chen, Zhen-Feng, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Dialdehydes; Oxazolidines
• Online Access: https://hdl.handle.net/10356/180941
• Institution: Nanyang Technological University

The first total synthesis of the monoterpene indole alkaloid (-)-deglycocadambine is achieved in 12 steps with (+)-genipin as the chiral starting material. The reported synthetic approach is characterized by an orchestrated cascade annulation between tryptamine and the highly functionalized dialdehy...