Multifunctional nanoparticle-loaded injectable alginate hydrogels with deep tumor penetration for enhanced chemo-immunotherapy of cancer

• Main Authors: Yang, Xinyu, Huang, Chenlu, Wang, Hanyong, Yang, Kaiyue, Huang, Mingyang, Zhang, Weijia, Yu, Qingyu, Wang, Hai, Zhang, Linhua, Zhao, Yanli, Zhu, Dunwan
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Chemo-immunotherapy; Enhanced tumor penetration
• Online Access: https://hdl.handle.net/10356/180957
• Institution: Nanyang Technological University

Chemo-immunotherapy has become a promising strategy for cancer treatment. However, the inability of the drugs to penetrate deeply into the tumor and form potent tumor vaccines in vivo severely restricts the antitumor effect of chemo-immunotherapy. In this work, an injectable sodium alginate platform...