Computational development of E3 ubiquitin ligase binding moieties in PROTACs

• المؤلف الرئيسي: Lam, Hilbert Yuen In
• مؤلفون آخرون: Mu Yuguang
• التنسيق: Final Year Project
• اللغة: English
• منشور في: Nanyang Technological University 2024
• الموضوعات: Medicine, Health and Life Sciences; PROTAC; Computer-aided drug discovery; Protein degradation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/180987
• المؤسسة: Nanyang Technological University

Proteolysis targeting chimaeras (PROTACs) are rapidly emerging small molecule drugs that exploit the cellular ubiquitin-proteasome pathway to degrade specific proteins of interest (POIs). Notably, PROTAC molecules consist of two separate moieties conjoined with a linker - one moiety binds to the POI...