Computational development of E3 ubiquitin ligase binding moieties in PROTACs

• Main Author: Lam, Hilbert Yuen In
• Other Authors: Mu Yuguang
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; PROTAC; Computer-aided drug discovery; Protein degradation
• Online Access: https://hdl.handle.net/10356/180987
• Institution: Nanyang Technological University

Proteolysis targeting chimaeras (PROTACs) are rapidly emerging small molecule drugs that exploit the cellular ubiquitin-proteasome pathway to degrade specific proteins of interest (POIs). Notably, PROTAC molecules consist of two separate moieties conjoined with a linker - one moiety binds to the POI...