Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

• Main Authors: Nair S., Bist P., Dikshit N., Krishnan M.N.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: beta interferon; interferon; interferon regulatory factor; small interfering RNA; STAT2 protein; ubiquitin protein ligase; ubiquitinated protein; antagonists and inhibitors; biology; drug effect; genetic transcription; genetics; HEK293 cell line; human; metabolism; reporter gene; RNA interference; signal transduction; Computational Biology; Genes, Reporter; HEK293 Cells; Humans; Interferon Regulatory Factors; Interferon Type I; Interferon-beta; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT2 Transcription Factor; Transcription, Genetic; Ubiquitin-Protein Ligases; Ubiquitinated Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174924
• Institution: National University of Singapore

10.1038/srep36179