Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

10.1038/srep36179

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Main Authors:	Nair S., Bist P., Dikshit N., Krishnan M.N.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	beta interferon interferon interferon regulatory factor small interfering RNA STAT2 protein ubiquitin protein ligase ubiquitinated protein antagonists and inhibitors biology drug effect genetic transcription genetics HEK293 cell line human metabolism reporter gene RNA interference signal transduction Computational Biology Genes, Reporter HEK293 Cells Humans Interferon Regulatory Factors Interferon Type I Interferon-beta RNA Interference RNA, Small Interfering Signal Transduction STAT2 Transcription Factor Transcription, Genetic Ubiquitin-Protein Ligases Ubiquitinated Proteins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174924
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1749242023-09-13T21:25:25Z Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling Nair S. Bist P. Dikshit N. Krishnan M.N. DUKE-NUS MEDICAL SCHOOL beta interferon interferon interferon regulatory factor small interfering RNA STAT2 protein ubiquitin protein ligase ubiquitinated protein antagonists and inhibitors biology drug effect genetic transcription genetics HEK293 cell line human metabolism reporter gene RNA interference signal transduction Computational Biology Genes, Reporter HEK293 Cells Humans Interferon Regulatory Factors Interferon Type I Interferon-beta RNA Interference RNA, Small Interfering Signal Transduction STAT2 Transcription Factor Transcription, Genetic Ubiquitin-Protein Ligases Ubiquitinated Proteins 10.1038/srep36179 Scientific Reports 6 36179 2020-09-09T01:25:30Z 2020-09-09T01:25:30Z 2016 Article Nair S., Bist P., Dikshit N., Krishnan M.N. (2016). Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling. Scientific Reports 6 : 36179. ScholarBank@NUS Repository. https://doi.org/10.1038/srep36179 20452322 https://scholarbank.nus.edu.sg/handle/10635/174924 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	beta interferon interferon interferon regulatory factor small interfering RNA STAT2 protein ubiquitin protein ligase ubiquitinated protein antagonists and inhibitors biology drug effect genetic transcription genetics HEK293 cell line human metabolism reporter gene RNA interference signal transduction Computational Biology Genes, Reporter HEK293 Cells Humans Interferon Regulatory Factors Interferon Type I Interferon-beta RNA Interference RNA, Small Interfering Signal Transduction STAT2 Transcription Factor Transcription, Genetic Ubiquitin-Protein Ligases Ubiquitinated Proteins
spellingShingle	beta interferon interferon interferon regulatory factor small interfering RNA STAT2 protein ubiquitin protein ligase ubiquitinated protein antagonists and inhibitors biology drug effect genetic transcription genetics HEK293 cell line human metabolism reporter gene RNA interference signal transduction Computational Biology Genes, Reporter HEK293 Cells Humans Interferon Regulatory Factors Interferon Type I Interferon-beta RNA Interference RNA, Small Interfering Signal Transduction STAT2 Transcription Factor Transcription, Genetic Ubiquitin-Protein Ligases Ubiquitinated Proteins Nair S. Bist P. Dikshit N. Krishnan M.N. Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
description	10.1038/srep36179
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Nair S. Bist P. Dikshit N. Krishnan M.N.
format	Article
author	Nair S. Bist P. Dikshit N. Krishnan M.N.
author_sort	Nair S.
title	Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
title_short	Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
title_full	Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
title_fullStr	Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
title_full_unstemmed	Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling
title_sort	global functional profiling of human ubiquitome identifies e3 ubiquitin ligase dcst1 as a novel negative regulator of type-i interferon signaling
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174924
_version_	1778169808317054976

Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

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