E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

• Main Authors: Bist P., Cheong W.S., Ng A., Dikshit N., Kim B.-H., Pulloor N.K., Khameneh H.J., Hedl M., Shenoy A.R., Balamuralidhar V., Malik N.B.A., Hong M., Neutzner A., Chin K.-C., Kobayashi K.S., Bertoletti A., Mortellaro A., Abraham C., MacMicking J.D., Xavier R.J., Sukumaran B.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: caspase recruitment domain protein 15; immunoglobulin enhancer binding protein; muramyl dipeptide; protein; protein rip2; protein znrf4; transcription factor RelA; ubiquitin protein ligase E3; unclassified drug; DNA binding protein; n acetylmuramylalanyl dextro isoglutamine; NOD2 protein, human; receptor interacting protein serine threonine kinase 2; RIPK2 protein, human; ZNRF4 protein, human; Znrf4 protein, mouse; bacterial disease; biodegradation; cell organelle; cells and cell components; enzyme; enzyme activity; immune response; immunity; peptide; rodent; animal experiment; Article; caspase activation and recruitment domain; controlled study; cytokine release; cytokine response; endoplasmic reticulum; human; human cell; in vitro study; in vivo study; monocyte; mouse; nonhuman; protein degradation; protein localization; protein protein interaction; regulatory mechanism; signal transduction; ubiquitination; animal; C57BL mouse; drug effect; genetics; HEK293 cell line; immunological tolerance; immunology; Listeria monocytogenes; listeriosis; metabolism; mutant mouse strain; pathogenicity; physiology; Bacteria (microorganisms); Mus; Acetylmuramyl-Alanyl-Isoglutamine; Animals; DNA-Binding Proteins; HEK293 Cells; Humans; Immune Tolerance; Listeriosis; Mice, Inbred C57BL; Mice, Mutant Strains; Monocytes; NF-kappa B; Nod2 Signaling Adaptor Protein; Receptor-Interacting Protein Serine-Threonine Kinase 2; Signal Transduction; Ubiquitination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174491
• Institution: National University of Singapore

10.1038/ncomms15865