E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

10.1038/ncomms15865

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Bibliographic Details
Main Authors:	Bist P., Cheong W.S., Ng A., Dikshit N., Kim B.-H., Pulloor N.K., Khameneh H.J., Hedl M., Shenoy A.R., Balamuralidhar V., Malik N.B.A., Hong M., Neutzner A., Chin K.-C., Kobayashi K.S., Bertoletti A., Mortellaro A., Abraham C., MacMicking J.D., Xavier R.J., Sukumaran B.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	caspase recruitment domain protein 15 immunoglobulin enhancer binding protein muramyl dipeptide protein protein rip2 protein znrf4 transcription factor RelA ubiquitin protein ligase E3 unclassified drug DNA binding protein n acetylmuramylalanyl dextro isoglutamine NOD2 protein, human receptor interacting protein serine threonine kinase 2 RIPK2 protein, human ZNRF4 protein, human Znrf4 protein, mouse bacterial disease biodegradation cell organelle cells and cell components enzyme enzyme activity immune response immunity peptide rodent animal experiment Article caspase activation and recruitment domain controlled study cytokine release cytokine response endoplasmic reticulum human human cell in vitro study in vivo study monocyte mouse nonhuman protein degradation protein localization protein protein interaction regulatory mechanism signal transduction ubiquitination animal C57BL mouse drug effect genetics HEK293 cell line immunological tolerance immunology Listeria monocytogenes listeriosis metabolism mutant mouse strain pathogenicity physiology Bacteria (microorganisms) Mus Acetylmuramyl-Alanyl-Isoglutamine Animals DNA-Binding Proteins HEK293 Cells Humans Immune Tolerance Listeriosis Mice, Inbred C57BL Mice, Mutant Strains Monocytes NF-kappa B Nod2 Signaling Adaptor Protein Receptor-Interacting Protein Serine-Threonine Kinase 2 Signal Transduction Ubiquitination
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174491
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Institution:	National University of Singapore

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