Computational development of E3 ubiquitin ligase binding moieties in PROTACs

• 主要作者: Lam, Hilbert Yuen In
• 其他作者: Mu Yuguang
• 格式: Final Year Project
• 語言: English
• 出版: Nanyang Technological University 2024
• 主題: Medicine, Health and Life Sciences; PROTAC; Computer-aided drug discovery; Protein degradation
• 在線閱讀: https://hdl.handle.net/10356/180987
• 機構: Nanyang Technological University

Proteolysis targeting chimaeras (PROTACs) are rapidly emerging small molecule drugs that exploit the cellular ubiquitin-proteasome pathway to degrade specific proteins of interest (POIs). Notably, PROTAC molecules consist of two separate moieties conjoined with a linker - one moiety binds to the POI...