Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax

Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax

Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed dea...

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Bibliographic Details
Main Authors: Christensen, Peter, Cinzah, Rosy, Suwanarusk, Rossarin, Chua, Adeline Chiew Yen, Kaneko, Osamu, Kyle, Dennis E., Aung, Htin Lin, Matheson, Jessica, Bifani, Pablo, Rénia, Laurent, Cook, Gregory M., Snounou, Georges, Russell, Bruce
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Antimalarial agents
Doxycycline
Online Access:https://hdl.handle.net/10356/181236
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Institution: Nanyang Technological University
Language: English
Description
Summary:Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline [IC50(96 h), 1,401 ± 607 nM]. As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 µM), and tafenoquine (1,424 nM) were not affected by extended exposure.

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