Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax

• المؤلفون الرئيسيون: Christensen, Peter, Cinzah, Rosy, Suwanarusk, Rossarin, Chua, Adeline Chiew Yen, Kaneko, Osamu, Kyle, Dennis E., Aung, Htin Lin, Matheson, Jessica, Bifani, Pablo, Rénia, Laurent, Cook, Gregory M., Snounou, Georges, Russell, Bruce
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Antimalarial agents; Doxycycline
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/181236

Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed dea...