Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and the metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze the production of reactive oxygen species (ROS...

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Main Authors: Zhang, Hanjie, Zhang, Yitong, Zhang, Yushi, Li, Hanyue, Ou, Meitong, Yu, Yongkang, Zhang, Fan, Yin, Huijuan, Mao, Zhuo, Mei, Lin
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Online Access:https://hdl.handle.net/10356/181243
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-181243
record_format dspace
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Medicine, Health and Life Sciences
Cancer therapy
Tumor cell line
spellingShingle Medicine, Health and Life Sciences
Cancer therapy
Tumor cell line
Zhang, Hanjie
Zhang, Yitong
Zhang, Yushi
Li, Hanyue
Ou, Meitong
Yu, Yongkang
Zhang, Fan
Yin, Huijuan
Mao, Zhuo
Mei, Lin
Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
description Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and the metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze the production of reactive oxygen species (ROS) without requiring external stimuli and the catalytic substrates are confirmed to be oxygen (O2) and hydrogen peroxide (H2O2) through the computational simulation and experiments. Considering the short of O2 and H2O2 at the tumor site, we utilize calcium peroxide (CaO2) to supply catalytic substrates for VPQDs and construct nanoparticles together with them, named VPCaNPs. VPCaNPs can induce oxidative stress in tumor cells, particularly characterized by a significant increase in hydroxyl radicals and superoxide radicals, which cause substantial damage to the structure and function of cells, ultimately leading to cell apoptosis. Intriguingly, O2 provided by CaO2 can degrade VPQDs slowly, and the degradation product, phosphate, as well as CaO2-generated calcium ions, can promote tumor calcification. Antitumor immune activation and less metastasis are also observed in VPCaNPs administrated animals. In conclusion, our study unveils the anti-tumor activity of VPQDs as catalysts for generating cytotoxic ROS and the degradation products can promote tumor calcification, providing a promising strategy for treating tumors.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Zhang, Hanjie
Zhang, Yitong
Zhang, Yushi
Li, Hanyue
Ou, Meitong
Yu, Yongkang
Zhang, Fan
Yin, Huijuan
Mao, Zhuo
Mei, Lin
format Article
author Zhang, Hanjie
Zhang, Yitong
Zhang, Yushi
Li, Hanyue
Ou, Meitong
Yu, Yongkang
Zhang, Fan
Yin, Huijuan
Mao, Zhuo
Mei, Lin
author_sort Zhang, Hanjie
title Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
title_short Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
title_full Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
title_fullStr Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
title_full_unstemmed Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
title_sort catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy
publishDate 2024
url https://hdl.handle.net/10356/181243
_version_ 1816859027770966016
spelling sg-ntu-dr.10356-1812432024-11-22T15:32:09Z Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy Zhang, Hanjie Zhang, Yitong Zhang, Yushi Li, Hanyue Ou, Meitong Yu, Yongkang Zhang, Fan Yin, Huijuan Mao, Zhuo Mei, Lin School of Chemistry, Chemical Engineering and Biotechnology Medicine, Health and Life Sciences Cancer therapy Tumor cell line Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and the metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze the production of reactive oxygen species (ROS) without requiring external stimuli and the catalytic substrates are confirmed to be oxygen (O2) and hydrogen peroxide (H2O2) through the computational simulation and experiments. Considering the short of O2 and H2O2 at the tumor site, we utilize calcium peroxide (CaO2) to supply catalytic substrates for VPQDs and construct nanoparticles together with them, named VPCaNPs. VPCaNPs can induce oxidative stress in tumor cells, particularly characterized by a significant increase in hydroxyl radicals and superoxide radicals, which cause substantial damage to the structure and function of cells, ultimately leading to cell apoptosis. Intriguingly, O2 provided by CaO2 can degrade VPQDs slowly, and the degradation product, phosphate, as well as CaO2-generated calcium ions, can promote tumor calcification. Antitumor immune activation and less metastasis are also observed in VPCaNPs administrated animals. In conclusion, our study unveils the anti-tumor activity of VPQDs as catalysts for generating cytotoxic ROS and the degradation products can promote tumor calcification, providing a promising strategy for treating tumors. Published version This study was supported by the National Natural Science Foundation of China (Grant No. 32301131, Z.M. and Grant No. 82272154, L.M.), Tianjin Science Fund for Distinguished Young Scholars (Grant No. 22JCJQJC00120, L.M.), the National Key Research and Development Program of China (Grant No. 2022YFE0139800, L.M.), the Fundamental Research Funds for the Central Universities (Grant No. 2021-RC310-005, L.M. and Grant No. 3332022070, Z.M.), Science and Technology Program of Tianjin City (the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region, Grant No. 22JCZXJC00060, L.M.), Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (Grant No. 2021-I2M-1-058, 2022-I2M-2-003, L.M. and Grant No. 2022-I2M-1-023, Z.M.), and the Fellowship of China Postdoctoral Science Foundation (Grant No. 2021M700502, Z.M.). 2024-11-19T02:17:40Z 2024-11-19T02:17:40Z 2024 Journal Article Zhang, H., Zhang, Y., Zhang, Y., Li, H., Ou, M., Yu, Y., Zhang, F., Yin, H., Mao, Z. & Mei, L. (2024). Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy. Nature Communications, 15(1), 6783-. https://dx.doi.org/10.1038/s41467-024-50769-0 2041-1723 https://hdl.handle.net/10356/181243 10.1038/s41467-024-50769-0 39117634 2-s2.0-85200838588 1 15 6783 en Nature Communications © 2024 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by-nc-nd/4.0/. application/pdf