Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have been unsuccessful in clinical trials. To address...

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Bibliographic Details
Main Authors: Koh, Javier Yu Peng, Itahana, Yoko, Krah, Alexander, Mostafa, Habib, Ong, Mingmin, Iwamura, Sahana, Vincent, Dona Mariya, Krishnan, Sabhashina Radha, Ye, Weiying, Yim, Pierre Wing Chi, Khopade, Tushar M., Chen, Kunihiko, Kong, Pui San, Wang, Lin-Fa, Bates, Roderick Wayland, Kimura, Yasuhisa, Viswanathan, Rajesh, Bond, Peter J., Itahana, Koji
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
ABCB1 Inhibitors
Drug resistant cancers
Online Access:https://hdl.handle.net/10356/181325
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/181325

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