Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

• Main Authors: Koh, Javier Yu Peng, Itahana, Yoko, Krah, Alexander, Mostafa, Habib, Ong, Mingmin, Iwamura, Sahana, Vincent, Dona Mariya, Krishnan, Sabhashina Radha, Ye, Weiying, Yim, Pierre Wing Chi, Khopade, Tushar M., Chen, Kunihiko, Kong, Pui San, Wang, Lin-Fa, Bates, Roderick Wayland, Kimura, Yasuhisa, Viswanathan, Rajesh, Bond, Peter J., Itahana, Koji
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; ABCB1 Inhibitors; Drug resistant cancers
• Online Access: https://hdl.handle.net/10356/181325
• Institution: Nanyang Technological University

Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have been unsuccessful in clinical trials. To address...