PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells

• Main Authors: Zhang, Meijian, Barroso, Emma, Peña, Lucía, Rada, Patricia, Valverde, Ángela M., Wahli, Walter, Palomer, Xavier, Vázquez-Carrera, Manuel
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; AMPK; Fibrosis
• Online Access: https://hdl.handle.net/10356/181357
• Institution: Nanyang Technological University

The role of peroxisome proliferator-activated receptor (PPAR)β/δ in hepatic fibrosis remains a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the pathogenesis of liver fibrosis and the activation of hepatic stellate cells (HSCs), the main effector cells in liver fibrosis, i...