Single-site nanozyme with exposed unsaturated Cu-O2 sites for tumor therapy by coordinating innate immunity and vasculature normalization

• Main Authors: Liu, Yang, Zhao, Huan, Niu, Rui, Zhang, Bin, Lim, Garrick Boon Teck, Song, Shuyan, Wang, Yinghui, Zhang, Hongjie, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Cuproptosis; Defective engineering
• Online Access: https://hdl.handle.net/10356/181694
• Institution: Nanyang Technological University

The low immunogenicity of tumors, coupled with abnormal and dysfunctional tumor vasculature, hinders the infiltration and function of effector T cells and suppresses the efficacy of immunotherapy. Herein, we developed a defective-copper-based metal-organic framework single-site nanozyme (F@D-CHTP SN...