Sonodynamic Nano-LYTACs reverse tumor immunosuppressive microenvironment for cancer immunotherapy

• Main Authors: Xu, Mengke, Hu, Yuxuan, Wu, Jiayan, Liu, Jing, Pu, Kanyi
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Medicine, Health and Life Sciences; Cancer; Cells
• Online Access: https://hdl.handle.net/10356/181951
• Institution: Nanyang Technological University

Extracellular and transmembrane proteins, which account for the products of approximately 40% of all protein-encoding genes in tumors, play a crucial role in shaping the tumor immunosuppressive microenvironment (TIME). While protein degradation therapy has been applied to membrane proteins of cancer...