Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population
While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asian...
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sg-ntu-dr.10356-1819882025-01-05T15:39:33Z Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population Ivan, Fransiskus Xaverius Tiew, Pei Yee Jaggi, Tavleen Kaur Thng, Kai Xian Pang, Pee Hwee Ong, Thun How Abisheganaden, John Arputhan Koh, Mariko Siyue Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) Interdisciplinary Graduate School (IGS) Tan Tock Seng Hospital Singapore General Hospital Medicine, Health and Life Sciences Metagenomics Microbiome While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asians using metagenomics. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Submitted/Accepted version This research is supported by the National Research Foundation Singapore under its Open Fund-Large Collaborative Grant (MOH-001636) and administered by the Singapore Ministry of Health's National Medical Research Council; Singapore Ministry of Health's National Medical Research Council under its Clinician–Scientist Individual Research Grant (MOH-001356) (S.H.C.), Clinician Scientist Award (MOH-000710) (S.H.C.) and Transition Award (MOH-001275-00) (P.Y.T.) and the Singapore Ministry of Education under its AcRF Tier 1 Grant (RT1/22) (S.H.C.). 2025-01-05T05:23:58Z 2025-01-05T05:23:58Z 2024 Journal Article Ivan, F. X., Tiew, P. Y., Jaggi, T. K., Thng, K. X., Pang, P. H., Ong, T. H., Abisheganaden, J. A., Koh, M. S. & Chotirmall, S. H. (2024). Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population. Respirology. https://dx.doi.org/10.1111/resp.14863 1323-7799 https://hdl.handle.net/10356/181988 10.1111/resp.14863 39622769 2-s2.0-85211119942 en RT1/22 MOH-000710 MOH-001275-00 MOH-001356 MOH-001636 Respirology © 2024 Asian Pacific Society of Respirology. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org//10.1111/resp.14863. application/pdf |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NTU Library |
| collection |
DR-NTU |
| language |
English |
| topic |
Medicine, Health and Life Sciences Metagenomics Microbiome |
| spellingShingle |
Medicine, Health and Life Sciences Metagenomics Microbiome Ivan, Fransiskus Xaverius Tiew, Pei Yee Jaggi, Tavleen Kaur Thng, Kai Xian Pang, Pee Hwee Ong, Thun How Abisheganaden, John Arputhan Koh, Mariko Siyue Chotirmall, Sanjay Haresh Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| description |
While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asians using metagenomics. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Ivan, Fransiskus Xaverius Tiew, Pei Yee Jaggi, Tavleen Kaur Thng, Kai Xian Pang, Pee Hwee Ong, Thun How Abisheganaden, John Arputhan Koh, Mariko Siyue Chotirmall, Sanjay Haresh |
| format |
Article |
| author |
Ivan, Fransiskus Xaverius Tiew, Pei Yee Jaggi, Tavleen Kaur Thng, Kai Xian Pang, Pee Hwee Ong, Thun How Abisheganaden, John Arputhan Koh, Mariko Siyue Chotirmall, Sanjay Haresh |
| author_sort |
Ivan, Fransiskus Xaverius |
| title |
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| title_short |
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| title_full |
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| title_fullStr |
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| title_full_unstemmed |
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population |
| title_sort |
sputum metagenomics reveals a multidrug resistant pseudomonas-dominant severe asthma phenotype in an asian population |
| publishDate |
2025 |
| url |
https://hdl.handle.net/10356/181988 |
| _version_ |
1821237109982232576 |