Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population

• Main Authors: Ivan, Fransiskus Xaverius, Tiew, Pei Yee, Jaggi, Tavleen Kaur, Thng, Kai Xian, Pang, Pee Hwee, Ong, Thun How, Abisheganaden, John Arputhan, Koh, Mariko Siyue, Chotirmall, Sanjay Haresh
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Metagenomics; Microbiome
• Online Access: https://hdl.handle.net/10356/181988
• Institution: Nanyang Technological University

While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asian...