The protective effects of Polygala tenuifolia and tenuifolin on corticosterone-evoked ferroptosis, oxidative stress, and neuroinflammation: insights from molecular dynamics simulations and in vitro experiments

• Main Authors: Xue, Chaoyi, He, Zhiyong, Zeng, Maomao, Wang, Zhaojun, Chen, Qiuming, Qin, Fang, Chen, Mingmin, Ye, Hui, Chen, Jie
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Tenuifolin; Ferroptosis
• Online Access: https://hdl.handle.net/10356/182121
• Institution: Nanyang Technological University

Excessive stress is a well-established contributor to neurological damage, insomnia, and depression, imposing a significant burden on individuals and society. This underscores the urgent need for effective stress-relief strategies. The main purpose of this study was to explore the protective effects...