A nitroreductase-activatable metabolic reporter for covalent labeling of pathological hypoxic cells in tumorigenesis

• Main Authors: Wang, Zhimin, Lau, Jun Wei, Liu, Songhan, Ren, Ziheng, Gong, Zhiyuan, Liu, Xiaogang, Xing, Bengang
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Metabolic glycan engineering; Nitroreductase-activatable
• Online Access: https://hdl.handle.net/10356/182206
• Institution: Nanyang Technological University

Aberrant hypoxic stress will initiate a cascade of pathological consequence observed prominently in tumorigenesis. Understanding of hypoxia's role in tumorigenesis is highly essential for developing effective therapeutics, which necessitates reliable tools to specifically distinguish hypoxic tu...