Elucidating antibiotic permeation through the Escherichia coli outer membrane: insights from molecular dynamics

• Main Authors: Deylami, Javad, Chng, Shu Sin, Yong, Ee Hou
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Antibiotics resistance; Atomistic modelling
• Online Access: https://hdl.handle.net/10356/182444
• Institution: Nanyang Technological University

Antibiotic resistance represents a critical public health threat, with an increasing number of Gram-negative pathogens demonstrating resistance to a broad range of clinical drugs. A primary challenge in enhancing antibiotic efficacy is overcoming the robust barrier presented by the bacterial outer m...