Robust catalytic SEAr H/D exchange of arenes with D2O: metal-free deuteration of natural complexes and drugs

A catalytic metal-free approach for the H/D exchange in aromatic compounds using D2O as the terminal deuterating reagent has been developed. This metal-free protocol employs a triaryl carbenium as the mediator and showcases a wide applicability in the late-stage deuteration of various natural produc...

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Bibliographic Details
Main Authors: Zhang, Zhenguo, Lv, Yongheng, Ong, Renee Wan Qing, Zhao, Xuefei, Jia, Zhenhua, Loh, Teck-Peng
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2025
Subjects:
Online Access:https://hdl.handle.net/10356/182584
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Institution: Nanyang Technological University
Language: English