Robust catalytic SEAr H/D exchange of arenes with D2O: metal-free deuteration of natural complexes and drugs
A catalytic metal-free approach for the H/D exchange in aromatic compounds using D2O as the terminal deuterating reagent has been developed. This metal-free protocol employs a triaryl carbenium as the mediator and showcases a wide applicability in the late-stage deuteration of various natural produc...
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Main Authors: | Zhang, Zhenguo, Lv, Yongheng, Ong, Renee Wan Qing, Zhao, Xuefei, Jia, Zhenhua, Loh, Teck-Peng |
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Other Authors: | School of Chemistry, Chemical Engineering and Biotechnology |
Format: | Article |
Language: | English |
Published: |
2025
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/182584 |
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Institution: | Nanyang Technological University |
Language: | English |
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