Decarboxylative coupling of ketoacids with allylic acetates

• Main Authors: Zhang, Xiaoyu, Hou, Fanyi, Zhang, Yinlei, Li, Bowen, Xie, Peizhong, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Acetic acid derivative; Itaconic acid
• Online Access: https://hdl.handle.net/10356/182587
• Institution: Nanyang Technological University

We developed a novel, metal-free catalytic system for synthesizing a broad range of itaconates using α-ketoacids and allylic acetate. This method, leveraging phosphine and Mes-Acr+(BF4-) catalysts, has proven versatile, enabling the efficient itaconation of peptides, the synthesis of bioactive itaco...