Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation

• Main Authors: Seankongsuk, Pattarakiat, Sae-Lao, Patcharaporn, He, Shi, Pereira, Veronica, Bates, Roderick W.
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry
• Online Access: https://hdl.handle.net/10356/182986
• Institution: Nanyang Technological University

The first asymmetric synthesis of (−)-dihydrogambirtannine has been achieved using nucleophilic addition to a chiral sulfinyl imine to establish the stereogenic centre and [2 + 2 + 2] alkyne cyclotrimerisation to construct the aromatic E ring.