Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation

The first asymmetric synthesis of (−)-dihydrogambirtannine has been achieved using nucleophilic addition to a chiral sulfinyl imine to establish the stereogenic centre and [2 + 2 + 2] alkyne cyclotrimerisation to construct the aromatic E ring.

Saved in:

Bibliographic Details
Main Authors:	Seankongsuk, Pattarakiat, Sae-Lao, Patcharaporn, He, Shi, Pereira, Veronica, Bates, Roderick W.
Other Authors:	School of Chemistry, Chemical Engineering and Biotechnology
Format:	Article
Language:	English
Published:	2025
Subjects:	Chemistry
Online Access:	https://hdl.handle.net/10356/182986
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-182986
record_format	dspace
spelling	sg-ntu-dr.10356-1829862025-03-14T15:32:09Z Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation Seankongsuk, Pattarakiat Sae-Lao, Patcharaporn He, Shi Pereira, Veronica Bates, Roderick W. School of Chemistry, Chemical Engineering and Biotechnology Chemistry The first asymmetric synthesis of (−)-dihydrogambirtannine has been achieved using nucleophilic addition to a chiral sulfinyl imine to establish the stereogenic centre and [2 + 2 + 2] alkyne cyclotrimerisation to construct the aromatic E ring. National Research Foundation (NRF) Published version We thank the National Research Foundation, Singapore, NRF Competitive Research Programme (CRP), grant numbers NRF-CRP27-2021-0002 and NRF-CRP18-2017-01, for financial support. We thank NTU for support. V. P. thanks the URECA programme of NTU. 2025-03-13T08:14:20Z 2025-03-13T08:14:20Z 2025 Journal Article Seankongsuk, P., Sae-Lao, P., He, S., Pereira, V. & Bates, R. W. (2025). Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation. Organic & Biomolecular Chemistry. https://dx.doi.org/10.1039/D5OB00162E 1477-0539 https://hdl.handle.net/10356/182986 10.1039/D5OB00162E en NRF-CRP27-2021-0002 NRF-CRP18-2017-01 Organic & Biomolecular Chemistry © The Royal Society of Chemistry 2025. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Chemistry
spellingShingle	Chemistry Seankongsuk, Pattarakiat Sae-Lao, Patcharaporn He, Shi Pereira, Veronica Bates, Roderick W. Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
description	The first asymmetric synthesis of (−)-dihydrogambirtannine has been achieved using nucleophilic addition to a chiral sulfinyl imine to establish the stereogenic centre and [2 + 2 + 2] alkyne cyclotrimerisation to construct the aromatic E ring.
author2	School of Chemistry, Chemical Engineering and Biotechnology
author_facet	School of Chemistry, Chemical Engineering and Biotechnology Seankongsuk, Pattarakiat Sae-Lao, Patcharaporn He, Shi Pereira, Veronica Bates, Roderick W.
format	Article
author	Seankongsuk, Pattarakiat Sae-Lao, Patcharaporn He, Shi Pereira, Veronica Bates, Roderick W.
author_sort	Seankongsuk, Pattarakiat
title	Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
title_short	Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
title_full	Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
title_fullStr	Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
title_full_unstemmed	Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
title_sort	synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation
publishDate	2025
url	https://hdl.handle.net/10356/182986
_version_	1827070707077480448

Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation

Similar Items