Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer's disease mouse model

• المؤلفون الرئيسيون: Wu, Xiaoting, Miller, James Alastair, Lee, Bernett Teck Kwong, Wang, Yulan, Ruedl, Christiane
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2025
• الموضوعات: Medicine, Health and Life Sciences; Alzheimer disease; Amyloid plaque
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/184421

Macrophages accumulate lipid droplets (LDs) under stress and inflammatory conditions. Despite the presence of LD-loaded macrophages in many tissues, including the brain, their contribution to neurodegenerative disorders remains elusive. This study investigated the role of lipid metabolism in Alzheim...