Functional and structural studies of the flavivirus RNA-dependent RNA polymerase

• المؤلف الرئيسي: Yap, Thai Leong
• مؤلفون آخرون: Subhash Vasudevan
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2009
• الموضوعات: DRNTU::Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/18856
• المؤسسة: Nanyang Technological University

Dengue fever, a neglected emerging disease for which no vaccine or antiviral agents exist at present, is caused by dengue virus, a member of the Flavivirus genus. The NS5 protein from dengue virus (DENV) is bi-functional and contains 900 amino acids. The S-adenosyl methionine transferase activity re...