Functional and structural studies of the flavivirus RNA-dependent RNA polymerase

• 主要作者: Yap, Thai Leong
• 其他作者: Subhash Vasudevan
• 格式: Theses and Dissertations
• 語言: English
• 出版: 2009
• 主題: DRNTU::Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids
• 在線閱讀: https://hdl.handle.net/10356/18856

Dengue fever, a neglected emerging disease for which no vaccine or antiviral agents exist at present, is caused by dengue virus, a member of the Flavivirus genus. The NS5 protein from dengue virus (DENV) is bi-functional and contains 900 amino acids. The S-adenosyl methionine transferase activity re...