Molecular mechanism of anion permeation through CFTR channel pore

• Main Author: Qian, Feng
• Other Authors: Gong Xiandi, Alex
• Format: Theses and Dissertations
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/19012
• Institution: Nanyang Technological University

Cystic fibrosis is an inherited disease caused by mutations in a single gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a member of ATP-binding cassette (ABC) proteins superfamily. Several approaches have been applied to determine the pore-lining domains or residues inc...