Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)

G-quadruplex DNA is formed by tetrads of guanines. It has an immense biological importance, yet it has extreme conformational diversity. Ensemble methods is not capable of observing these structural dynamics. Single-molecule techniques has come to rescue due to its capability to probe individual...

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Main Author:	Ricksen Surya Winardhi.
Other Authors:	Phan Anh Tuan
Format:	Final Year Project
Language:	English
Published:	2009
Subjects:	DRNTU::Science::Physics
Online Access:	http://hdl.handle.net/10356/19304
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-19304
record_format	dspace
spelling	sg-ntu-dr.10356-193042023-02-28T23:16:17Z Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET) Ricksen Surya Winardhi. Phan Anh Tuan School of Physical and Mathematical Sciences DRNTU::Science::Physics G-quadruplex DNA is formed by tetrads of guanines. It has an immense biological importance, yet it has extreme conformational diversity. Ensemble methods is not capable of observing these structural dynamics. Single-molecule techniques has come to rescue due to its capability to probe individual molecule and its time trajectories. In this project, single-molecule Forster resonance energy transfer system is constructed, and this state of the art system will be used for studying single G-quadruplex DNA dynamics. The result reveals the time trajectories of single G-quadruplex conformational changes, as well as the proposed conformations associated with it. Bachelor of Science in Physics 2009-12-03T07:59:42Z 2009-12-03T07:59:42Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/19304 en 85 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Physics
spellingShingle	DRNTU::Science::Physics Ricksen Surya Winardhi. Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
description	G-quadruplex DNA is formed by tetrads of guanines. It has an immense biological importance, yet it has extreme conformational diversity. Ensemble methods is not capable of observing these structural dynamics. Single-molecule techniques has come to rescue due to its capability to probe individual molecule and its time trajectories. In this project, single-molecule Forster resonance energy transfer system is constructed, and this state of the art system will be used for studying single G-quadruplex DNA dynamics. The result reveals the time trajectories of single G-quadruplex conformational changes, as well as the proposed conformations associated with it.
author2	Phan Anh Tuan
author_facet	Phan Anh Tuan Ricksen Surya Winardhi.
format	Final Year Project
author	Ricksen Surya Winardhi.
author_sort	Ricksen Surya Winardhi.
title	Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
title_short	Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
title_full	Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
title_fullStr	Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
title_full_unstemmed	Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)
title_sort	single-molecule study of dna structure and dynamics by forster resonance energy transfer (fret)
publishDate	2009
url	http://hdl.handle.net/10356/19304
_version_	1759856386277113856

Single-molecule study of DNA structure and dynamics by Forster Resonance Energy Transfer (FRET)

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