IGF-1 stimulation via GSK-3β and screening for genes conferring protection of SHEP-1 cells against MPP+ toxicity

• المؤلف الرئيسي: Li, Jikun
• مؤلفون آخرون: Feng Zhiwei
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2009
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/19313
• المؤسسة: Nanyang Technological University

1-methyl-4-phenylpyridinium (MPP+) causes Parkinsonism and has been widely used in experimental models of Parkinson’s disease. MPP+ was used to induce apoptosis in human dopaminergic neural SHEP-1 cells in order to identify and characterise genes that may protect against MPP+ toxicity. In this stud...