IGF-1 stimulation via GSK-3β and screening for genes conferring protection of SHEP-1 cells against MPP+ toxicity

• Main Author: Li, Jikun
• Other Authors: Feng Zhiwei
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/19313
• Institution: Nanyang Technological University

1-methyl-4-phenylpyridinium (MPP+) causes Parkinsonism and has been widely used in experimental models of Parkinson’s disease. MPP+ was used to induce apoptosis in human dopaminergic neural SHEP-1 cells in order to identify and characterise genes that may protect against MPP+ toxicity. In this stud...