Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery

• Main Author: Kong, Wai Tuck.
• Other Authors: Hu Xiao
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Engineering::Materials::Biomaterials
• Online Access: http://hdl.handle.net/10356/35521
• Institution: Nanyang Technological University

pH responsive properties of poly(methacrylic acid) (PMAA) grafted nano-sized hollow silica (PMAA-g-HSi) were characterized, and better formulation of sulfasalazine (an anti-inflammatory pro-drug used for bowel disease) was pursued using PMAA-g-HSi. To investigate pH responsive behaviour of PMAA-g...