Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products

251 p.

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Bibliographic Details
Main Author:	Chan, Kok Ping
Other Authors:	Loh Teck Peng
Format:	Theses and Dissertations
Published:	2010
Subjects:	DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Online Access:	https://hdl.handle.net/10356/35719
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-357192023-02-28T23:33:47Z Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products Chan, Kok Ping Loh Teck Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis 251 p. Prins cyclization is one of the most convergent strategies for the synthesis of 2,6-disubstituted tetrahydropyran rings from homoallylic alcohols and aldehydes. However, several limitations, such as the possibility of racemization of the homoallylic alcohol and substrate compatibility, have rendered this methodology a less preferred choice in the total synthesis of natural products containing the THP motifs. The emphasis of this thesis is placed on the evolution of a novel catalytic Prins cyclization to overcome these current limitations, and manifestation of its applicability to the enantioselective synthesis of natural products. DOCTOR OF PHILOSOPHY (SPMS) 2010-04-23T01:28:20Z 2010-04-23T01:28:20Z 2007 2007 Thesis Chan, K. P. (2007). Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/35719 10.32657/10356/35719 application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
spellingShingle	DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis Chan, Kok Ping Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
description	251 p.
author2	Loh Teck Peng
author_facet	Loh Teck Peng Chan, Kok Ping
format	Theses and Dissertations
author	Chan, Kok Ping
author_sort	Chan, Kok Ping
title	Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
title_short	Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
title_full	Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
title_fullStr	Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
title_full_unstemmed	Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
title_sort	development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products
publishDate	2010
url	https://hdl.handle.net/10356/35719
_version_	1759853399644307456

Development of new methods in tetrahydropyran ring synthesis : application to enantioselective synthesis of natural products

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