Curved oligonucleotide constructs as human topoisomerase I inhibitors : a mechanistic study of the enzyme’s recognizing passway.
Topoisomerases I are enzymes that alter the topological states of DNA. In eukaryotic organisms, including human being, Topoisomerase I is diverse and significant. It is discovered that there are more than normal amount of Topo I enzymes in the tumour cells, making it a potential drug target for canc...
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| 格式: | Final Year Project |
| 語言: | English |
| 出版: |
2010
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| 在線閱讀: | http://hdl.handle.net/10356/38601 |
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| 機構: | Nanyang Technological University |
| 語言: | English |