Curved oligonucleotide constructs as human topoisomerase I inhibitors : a mechanistic study of the enzyme’s recognizing passway.

• Main Author: Zhao, Guanjia.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/38601
• Institution: Nanyang Technological University

Topoisomerases I are enzymes that alter the topological states of DNA. In eukaryotic organisms, including human being, Topoisomerase I is diverse and significant. It is discovered that there are more than normal amount of Topo I enzymes in the tumour cells, making it a potential drug target for canc...