Curved oligonucleotide constructs as human topoisomerase I inhibitors : a mechanistic study of the enzyme’s recognizing passway.

• المؤلف الرئيسي: Zhao, Guanjia.
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2010
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/38601
• المؤسسة: Nanyang Technological University

Topoisomerases I are enzymes that alter the topological states of DNA. In eukaryotic organisms, including human being, Topoisomerase I is diverse and significant. It is discovered that there are more than normal amount of Topo I enzymes in the tumour cells, making it a potential drug target for canc...