Recognition of forcibly curved DNA by human topoisomerase I.

• Main Author: Zhang, Yi.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: http://hdl.handle.net/10356/38616
• Institution: Nanyang Technological University

Human topoisomerase I is a group of enzyme that is responsible for the interconversions of different topological forms of DNA molecules in vivo. One of the most significant function of it is untangling the supercoiling in DNA molecules during cellular metabolic processes like replication and transcr...