The Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases

• المؤلفون الرئيسيون: Lv, Bei, Dai, Yunjia, Liu, Ju, Zhuge, Qiang, Li, Dawei
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Chemistry and Biological Chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81342; http://hdl.handle.net/10220/39218
• المؤسسة: Nanyang Technological University

The effects of dimethyl sulfoxide (DMSO) on supercoiled plasmid DNA relaxation catalyzed by two typical type I topoisomerases were investigated in our studies. It is shown that DMSO in a low concentration (less than 20%, v/v) can induce a dose-related enhancement of the relaxation efficiency of Esch...