Exploring age-dependent regulation of tyrosine hydroxylase in mice lacking the dopamine transporter.

• Main Author: Lim, Gerard Shing-Wan.
• Other Authors: Zhang Xiaodong
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: http://hdl.handle.net/10356/38733
• Institution: Nanyang Technological University

Dopamine (DA) plays a critical role in cognition and reward. Therefore, dysregulation of DA neurotransmission has been implicated in neurological diseases such as Parkinson’s disease, and psychiatric disorders such as attention-deficit hyperactive disorder. Tyrosine hydroxylase (TH) is the rate-limi...