Reproducibility analysis in sensorimotor and language tasks: implications for clinical functional magnetic resonance imaging.
In clinical functional magnetic resonance imaging (fMRI), p-value thresholds are typically applied to activation maps to investigate activation intensity. Problems with this methodology include: 1) averaging conceals richness of data, 2) appropriate p-values, 3) emphasis on small p-values, and 4)...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/38767 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | In clinical functional magnetic resonance imaging (fMRI), p-value thresholds are typically
applied to activation maps to investigate activation intensity. Problems with this methodology
include: 1) averaging conceals richness of data, 2) appropriate p-values, 3) emphasis on small
p-values, and 4) moderately activated functional regions cannot surpass rigorous p-value
thresholds. Similar challenges arise when applying clinical fMRI to evaluate a single patient,
in addition to a lack of normative standards for comparison. We propose using reproducibility
analysis (RA) with the thresholding method to provide an added dimension of information:
reliability of a brain region’s activation over time. We found that sensorimotor tasks
involving primary cortical areas produced more robust and reproducible activations than
language tasks involving higher cognition and association cortex. |
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