Human α-lactalbumin made lethal to tumor cell death (HAMLET) mediates amyloid precursor protein (APP) in inducing cell death.

• Main Author: Toh, Kah Peng.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/38867
• Institution: Nanyang Technological University

HAMLET (Human α-lactalbumin made lethal to tumor cells) is a complex formed by the binding of partially unfolded α-lactalbumin and oleic acid in an ion exchange chromatography. It possesses tumoricidal activity by triggering tumor cell death, however, leaving the healthy differentiated cells unaffec...