Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells.
Dendritic cells (DC) originate from hematopoietic precursors and they detect endogenous and exogenous stimuli which lead to an inflammatory response. The “inflammasome” is a large protein complex which consists of Caspase-1 and Pycard/ASC which are involved in IL-1β and IL-18 processing. However, th...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/39450 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |