N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.

• Main Author: Wong, Qian Ling.
• Other Authors: Liu Xuewei
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: http://hdl.handle.net/10356/39818
• Institution: Nanyang Technological University

A mild and efficient method for an intramolecular carbon-carbon bond formation between sp2 carbon (aldehyde) and sp carbon (activated alkyne) has been developed using N-Heterocyclic carbene catalyst. This method allows the usage of salicylaldehyde derivatives to assemble a wide pool of chromone deri...