N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.

A mild and efficient method for an intramolecular carbon-carbon bond formation between sp2 carbon (aldehyde) and sp carbon (activated alkyne) has been developed using N-Heterocyclic carbene catalyst. This method allows the usage of salicylaldehyde derivatives to assemble a wide pool of chromone deri...

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Main Author: Wong, Qian Ling.
Other Authors: Liu Xuewei
Format: Final Year Project
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/39818
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-398182023-02-28T23:16:43Z N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones. Wong, Qian Ling. Liu Xuewei School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds A mild and efficient method for an intramolecular carbon-carbon bond formation between sp2 carbon (aldehyde) and sp carbon (activated alkyne) has been developed using N-Heterocyclic carbene catalyst. This method allows the usage of salicylaldehyde derivatives to assemble a wide pool of chromone derivatives in a straightforward and expeditious manner. The optimized reaction conditions include the employment of a thiazolium pre-catalyst (D) in the presence of Et3N, dissolved in dry DMF solvent and stirred at room temperature for 24 hours. 17 substrates had been screened and most of them afforded promising yields of 70-85%. Furthermore, we envisage the application of this method on aliphatic systems to access more heterocycles. Bachelor of Science in Chemistry and Biological Chemistry 2010-06-04T06:53:10Z 2010-06-04T06:53:10Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/39818 en 94 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
spellingShingle DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
Wong, Qian Ling.
N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
description A mild and efficient method for an intramolecular carbon-carbon bond formation between sp2 carbon (aldehyde) and sp carbon (activated alkyne) has been developed using N-Heterocyclic carbene catalyst. This method allows the usage of salicylaldehyde derivatives to assemble a wide pool of chromone derivatives in a straightforward and expeditious manner. The optimized reaction conditions include the employment of a thiazolium pre-catalyst (D) in the presence of Et3N, dissolved in dry DMF solvent and stirred at room temperature for 24 hours. 17 substrates had been screened and most of them afforded promising yields of 70-85%. Furthermore, we envisage the application of this method on aliphatic systems to access more heterocycles.
author2 Liu Xuewei
author_facet Liu Xuewei
Wong, Qian Ling.
format Final Year Project
author Wong, Qian Ling.
author_sort Wong, Qian Ling.
title N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
title_short N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
title_full N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
title_fullStr N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
title_full_unstemmed N-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
title_sort n-heterocyclic carbene-catalyzed intramolecular stetter reaction between an aldehyde and activated alkyne for easy access to chromones.
publishDate 2010
url http://hdl.handle.net/10356/39818
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