Understanding the role of Brd4 in the maintenance of human embryonic stem cells.

• Main Author: Lim, Michelle Gek Liang.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Human embryology
• Online Access: http://hdl.handle.net/10356/39821
• Institution: Nanyang Technological University

Brd4 is a bromodomain protein of the BET family and has been implicated in the cell cycle, transcription, and epigenetics. While Brd4 has been studied in mouse cells and HeLa cells, its role in human embryonic stem cell (hESC) has not been elucidated. In the present study, we investigated the role o...